All About PDE-5 Inhibitors: Its Uses, Effects, Natural Sources

PDE-5 can be abbreviated as phosphodiesterase type 5 inhibitor that can be termed as a Vasodilating drug and is used majorly to treat erectile dysfunction. They generally can improve the symptoms of erectile dysfunction and this was discovered accidentally in research. PDE-5 inhibitors are also applied to treat blood pressure and angina in many cases. Erectile dysfunction is a common condition in men and about 30-50 million men are suffering from it. PDE-5 inhibitors are the first-line therapy used to combat poor blood flow and treat erectile dysfunction. It shows action by blocking the degradation mechanism of cGMP-specific PDE-5 on smooth muscles. 

What Does PDE-5 Stand For In Pharmacy?

According to pharmacology, phosphodiesterase inhibitors can block the action of any of the five types of enzyme phosphodiesterase that further prevents the inactivation of intracellular second messengers. There are four PDE-5 inhibitors available in the market, and all of them are mainly intended to treat erectile dysfunction. These PDE-5 inhibitors are Sildenafil Citrate, Tadalafil, Vardenafil, and Avanafil. PDE-5 inhibitors can also help you combat pulmonary arterial hypertension. PDE-5 is generally advised to be consumed orally and in the form of tablets.

Which Body Part Creates The PDE-5 Inhibitor?

The human body is known to have naturally found PDE-5 enzymes. It can be found in the smooth muscles present in the corpus cavernosum that are responsible for degrading cGMP to 5′-GMP. The structure of PDE-5 inhibitors is extremely similar to the cGMP structure. Hence when you consume PDE-5 inhibitors it will bind to PDE-5 enzymes. This process further restricts the hydrolysis of cGMP. This whole process governs the increased production of nitric oxide. This is why PDE-5 triggers erection in men.

What Is the Effect of the PDE-5 Quizlet?

What are the goals of phosphodiesterase type 5 inhibitors?

●   To treat and reverse erectile dysfunction in men.

●   Help combat pulmonary arterial hypertension.

What mechanism do PDE-5 inhibitor follow?

These PDE-5 inhibitors show their action by increasing the blood flow to the penis. Its entire mechanism is conducted through Vasodilation.

What side effects are associated with the usage of PDE-5 inhibitor?

  • Feeling of dizziness
  • Headache and lightheadedness
  • Flushing and diarrhoea
  • Stuffed and runny nose
  • Dyspepsia and Rhinitis

How many PDE-5 inhibitors are available in the market?

There are five types of PDE-5 inhibits medicines available namely:

What Is the Effect of PDE-5?

PDE-5 is an enzyme present in the human body. It is nothing but an enzyme responsible for bringing down an erection in men. This enzyme is found in the walls of blood vessels. It is considered to be an important enzyme that regulates cGMP-specific signaling in psychological operations such as the relaxation and contraction in the smooth muscles. 

Hence when you consume an inhibitor it can help you alter the conditions associated with low cGMP production. PDE-5 inhibitors are specially crafted to hinder the mechanism of naturally occurring PDE-5 enzymes. 

What Herbs Have PDE-5 Inhibitors in Them?

There exist herbs that possess inhibiting properties and can be recognized as PDE-5 inhibitors. One of those herbs is Kaempferia parviflora. This is a herbal plant that has the natural presence of PDE-5 inhibitors. It restricts the action of the PDE-5 enzymes that already exist in the walls of vessels to enhance relaxation. It also positively affects blood flow and the signaling system. Also, researchers are looking at horny goat weed as a PDE-5 inhibitor. It is assumed to contain Icarlin that is a PDE-5 inhibitor but a mild one.

What Are Natural PDE-5 Inhibitors?

PDE-5 inhibitors are the one that restricts the action of naturally occurring PDE-5 enzyme found in the walls of the vessels. Keeping the artificial PDE-5 inhibitors aside there are few natural inhibitors discovered that can show up results with minimal side effects.  The list of natural PDE-5 inhibitors include:

  • Kaempferia Parviflora
  • Horny Goat Weed
  • Pomegranate juice

All of these are assumed to possess the properties to inhibit the mechanism of the PDE-5 enzyme and hence are termed to be a natural PDE-5 inhibitor. Researches are going on to find out the exact results.

How PDE-5 Inhibitor Works In The Body?

PDE-5 inhibitor has its meaning in the name itself, it works by inhibiting. PDE-5 inhibitors generally ensure a good amount of blood flow to the pulmonary arteries by stopping the mechanism of the PDE-5 enzyme. 

While the PDE-5 enzyme is known to given contraction and relaxation of blood vessels, you can ensure relaxation for proper blood flow by impeding its action. This entire mechanism is governed by ensuring a high level of cGMP that further increases the production of nitric oxide. Hence consuming PDE-5 inhibitors can furnish a man with a firm erection.

What Activates PDE-5?

You don’t need to active PDE-5 externally, as it directly activates as cGMP compels to its GAF A domain. If cGMP does not get bound to its domain PDE-5 remains inactivated. Just on binding it directly gets activated. 

This activation in the mechanism of the PDE-5 enzyme cuts off the blood supply to the penis leading to a breakdown in an erection. While you consume a PDE-5 inhibitor, it restricts the action of the PDE-5 enzyme by not letting it bind to the cGMP.

What Is The Longest-lasting PDE-5 Inhibitor?

Among all the PDE-5 inhibitors developed to treat Erectile Dysfunction, the longest lasting one is Tadalafil. It can last in the body for almost 17.5 hours. And according to an estimation, Tadalafil can last fully up to 24 to 36 hours. 

In rare cases, this might go up to 72 hours. If you just take a typical dose of 2 to 2.5 mg it will not fade away in less than 24 hours and hence doctor prescribes it carefully to avoid buildup.


PDE-5 inhibitors are developed to treat erectile dysfunction by impeding the function of the PDE-5 enzyme present in the blood vessels. It causes the sensation of relaxation in those vessels leading to superior blood flow to the penis that contributes to a long-lasting and firm erection. 

You must consume any of the PDE-5 inhibitor after getting a prescription from a doctor or else it could be harmful to you. These inhibitors can also be used to treat patients with pulmonary arterial hypertension.

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